{"id":39546,"date":"2016-02-22T06:41:32","date_gmt":"2016-02-22T01:11:32","guid":{"rendered":"https:\/\/new.editage.cn\/insights\/%e5%85%a8%e7%90%83%e7%9f%a5%e5%90%8d%e7%94%9f%e7%89%a9%e5%88%b6%e8%8d%af%e5%85%ac%e5%8f%b8%e5%ae%89%e8%bf%9b%ef%bc%88amgen%ef%bc%89%e5%8f%91%e8%a1%a8%e5%a4%b1%e8%b4%a5%e7%9a%84%e7%a0%94%e7%a9%b6"},"modified":"2026-01-07T16:24:09","modified_gmt":"2026-01-07T10:54:09","slug":"quan-qiu-zhi-ming-sheng-wu-zhi-yao-gong-si-an-jin-amgen-fa-biao-shi-bai-de-yan-jiu-jie-guo-gai-jin-ke-xue-zi-w-2521","status":"publish","type":"post","link":"https:\/\/new.editage.cn\/insights\/quan-qiu-zhi-ming-sheng-wu-zhi-yao-gong-si-an-jin-amgen-fa-biao-shi-bai-de-yan-jiu-jie-guo-gai-jin-ke-xue-zi-w-2521\/","title":{"rendered":"\u5168\u7403\u77e5\u540d\u751f\u7269\u5236\u836f\u516c\u53f8\u5b89\u8fdb\uff08Amgen\uff09\u53d1\u8868\u5931\u8d25\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u6539\u8fdb\u79d1\u5b66\u81ea\u6211\u7ea0\u6b63\u7684\u529f\u80fd"},"content":{"rendered":"<p>\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u52a0\u5dde\u7684\u8de8\u56fd\u751f\u7269\u5236\u836f\u516c\u53f8\u5b89\u8fdb\uff08Amgen\uff09\u5728 2 \u6708 4 \u65e5<a href=\"https:\/\/blog.f1000research.com\/wordpresshttps:\/\/new.editage.cn\/insights\/wp-content\/uploads\/2025\/12\/2016\/02\/Amgen-final-press-release.pdf\" rel=\"nofollow\" target=\"_blank\">\u5ba3\u5e03<\/a>\u5c06\u53d1\u8868 3 \u4e2a\u65e0\u6cd5\u786e\u8ba4\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u8fd9 3 \u4e2a\u7814\u7a76\u5c06\u4f1a\u53d1\u8868\u5728 <a href=\"https:\/\/f1000research.com\/channels\/PRR\" rel=\"nofollow\" target=\"_blank\">F1000<\/a> \u65b0\u63a8\u51fa\u4e0d\u4e45\u7684\u53d1\u8868\u5e73\u53f0\u00a0<a href=\"https:\/\/f1000research.com\/channels\/PRR\" rel=\"nofollow\" target=\"_blank\">Preclinical Reproducibility and Robustness<\/a>\u00a0\u4e0a\u3002\u5b89\u8fdb\u7814\u7a76\u53d1\u73b0\u9ad8\u7ea7\u526f\u603b Sasha Kamb \u5728\u65b0\u95fb\u7a3f\u4e2d\u63d0\u5230\uff0c\u505a\u51fa\u8fd9\u4e2a\u51b3\u5b9a\u80cc\u540e\u7684\u4e3b\u8981\u539f\u56e0\u662f\u8981\u201c\u6539\u5584\u5c06\u57fa\u7840\u53d1\u73b0\u8f6c\u5316\u6210\u65b0\u836f\u7269\u7684\u6548\u7387\u4e0e\u901f\u5ea6\uff0c\u56e0\u6b64\u8981\u51cf\u5c11\u91cd\u590d\u7814\u7a76\u7684\u6d6a\u8d39\u3001\u672a\u516c\u5f00\u7684\u4e0d\u786e\u5b9a\u53d1\u73b0\uff0c\u8ba9\u6211\u4eec\u80fd\u4e13\u6ce8\u5728\u771f\u6b63\u7684\u7a81\u7834\u4e0a\u3002\u201d<\/p>\n<p>\u7531\u4e8e\u4f20\u7edf\u7684\u53d1\u8868\u65b9\u5f0f\u5f88\u8017\u65f6\uff0cKamb \u9009\u62e9\u5f00\u653e\u83b7\u53d6\u671f\u520a F1000Research \u8fdb\u884c\u53d1\u8868\uff0c\u8be5\u671f\u520a\u53ea\u9700\u8981\u7f16\u8f91\u68c0\u67e5\u5c31\u4f1a\u5728\u540c\u884c\u8bc4\u5ba1\u524d\u8fdb\u884c\u5728\u7ebf\u53d1\u8868\u3002\u53d1\u8868\u7684\u7814\u7a76\u4f1a\u7ecf\u8fc7\u53d1\u8868\u540e\u540c\u884c\u8bc4\u5ba1\uff0c\u7ecf\u8fc7\u5ba1\u7a3f\u4eba\u5efa\u8bae\uff0c\u5c31\u6709\u53ef\u80fd\u7b26\u5408\u6536\u5f55\u8d44\u683c\u3002<a href=\"https:\/\/f1000research.com\/\" rel=\"nofollow\" target=\"_blank\">F1000Research<\/a>\u00a0\u7684\u987e\u95ee\u56e2\u6210\u5458\u00a0Bruce Alberts \u8bf4\u5230\u00a0Preclinical Reproducibility and Robustness \u7684\u521b\u7acb\u5b97\u65e8\u662f<a href=\"https:\/\/www.nature.com\/news\/biotech-giant-publishes-failures-to-confirm-high-profile-science-1.19269#\/b1\" rel=\"nofollow\" target=\"_blank\">\u9f13\u52b1\u7814\u7a76\u4eba\u5458\u5206\u4eab\u90a3\u4e9b\u7ecf\u5e38\u65e0\u6cd5\u53d1\u8868\u7684\u8d1f\u9762\u7ed3\u679c<\/a>\u3002<\/p>\n<p>\u5b89\u8fdb\u5148\u524d\u6709\u8fc7\u51e0\u8d77\u7814\u7a76\u7ed3\u679c\u65e0\u6cd5\u590d\u5236\u7684\u4e89\u8bae\u30022012 \u5e74\uff0c\u5b89\u8fdb\u7684\u7814\u7a76\u4eba\u5458\u5ba3\u79f0<a href=\"https:\/\/www.reuters.com\/article\/us-science-cancer-idUSBRE82R12P20120328\" rel=\"nofollow\" target=\"_blank\">\u5728 53 \u7bc7\u5177\u6709\u764c\u75c7\u7a81\u7834\u6027\u7684\u8bba\u6587\u4e2d\uff0c\u6709 43 \u7bc7\u65e0\u6cd5\u590d\u5236<\/a>\uff0cKamb \u6f84\u6e05\uff0c\u8fd9\u6b21\u8981\u53d1\u8868\u7684 3 \u4e2a\u7814\u7a76\u8ddf\u8fd9\u4e9b\u8bba\u6587\u65e0\u5173\uff0c<a href=\"https:\/\/www.nature.com\/news\/biotech-giant-publishes-failures-to-confirm-high-profile-science-1.19269#\/b2\" rel=\"nofollow\" target=\"_blank\">\u300a\u81ea\u7136\u300b\u6587\u7ae0<\/a>\u63d0\u5230\uff1a\u300c\u4e00\u9879\u7814\u7a76\u662f\u5173\u4e8e\u300a\u79d1\u5b66\u300b\u53d1\u8868\u8fc7\u7684\u4e00\u7bc7\u8bba\u6587\uff0c<a href=\"https:\/\/science.sciencemag.org\/content\/335\/6075\/1503\" rel=\"nofollow\" target=\"_blank\">\u5173\u4e8e\u764c\u75c7\u836f\u7269\u53ef\u7528\u6765\u6cbb\u7597\u963f\u5179\u6d77\u9ed8\u75be\u75c5<\/a>\uff0c\u8fd9\u4e2a\u7814\u7a76\u73b0\u6709\u4e00\u4e9b\u6279\u5224\uff0c\u800c\u5b89\u8fdb\u7684\u7814\u7a76\u7ed3\u679c\u4e5f\u52a0\u5165\u4e86\u6279\u5224\u884c\u5217\uff1b\u7b2c\u4e8c\u4e2a\u7814\u7a76\u5219\u662f\u5c5e\u4e8e<a href=\"https:\/\/insulin sensitivity\" rel=\"nofollow\" target=\"_blank\">\u5c0f\u9f20\u4e2d\u7684\u4e00\u4e2a\u57fa\u56e0\u4e0e\u80f0\u5c9b\u7d20\u654f\u611f\u6027\u6709\u5173<\/a>\u7684<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0006291X11021450\" rel=\"nofollow\" target=\"_blank\">\u65e9\u671f\u53d1\u73b0<\/a>\uff08\u5176\u4e2d\u6709\u90e8\u5206\u662f\u5b89\u8fdb\u7684\u7814\u7a76\u4eba\u5458\uff09\uff1b\u800c\u7b2c\u4e09\u4e2a\u7814\u7a76\u5219\u662f\u5173\u4e8e\u300a\u81ea\u7136\u300b\u7684<a href=\"https:\/\/www.nature.com\/articles\/nature09299.epdf?referrer_access_token=e4AFM6kZqIjjIXI_Q-DPaNRgN0jAjWel9jnR3ZoTv0OLxaVo8nRLk3exGIwllCLBGHvxg2XVbtW_lxD4w2fvVIHyYwx5M96B8c7eQ3B-qVOlPJPTHdGtUc2yIEiE_HkoC3LBPwtYtAcvaWo8REfTonjYf_m6OjflgwH2nxgbSOh9jvcg59H7uLJBjO5dPlyC054VSrvPQKqk5JpGx1Ry_3K9Upvwl9pq40lJQV_qI_WUUvCTzHaVHunfbk_NDnAU&amp;tracking_referrer=www.nature.com\" rel=\"nofollow\" target=\"_blank\">\u4e00\u7bc7\u8bba\u6587<\/a>\uff0c\u6291\u5236\u67d0\u4e2a\u86cb\u767d\u8d28\u53ef\u4ee5\u589e\u52a0\u4e0e\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u6709\u5173\u7684\u5176\u4ed6\u86cb\u767d\u8d28\u7684\u964d\u89e3\u3002\u300dKamb \u5e0c\u671b\u5176\u4ed6\u516c\u53f8\u4e5f\u80fd\u52a0\u5165\u5b89\u8fdb\u7684\u884c\u5217\uff0c\u4e00\u8d77\u53d1\u8868\u8d1f\u9762\u7684\u7814\u7a76\u7ed3\u679c\uff0c\u5e2e\u52a9\u79d1\u7814\u8fdb\u6b65\u7684\u901f\u5ea6\u3002<\/p>\n<p>\u867d\u7136\u6709\u8bb8\u591a\u7814\u7a76\u4eba\u5458\u90fd\u652f\u6301\u5b89\u8fdb\u7684\u8fd9\u4e2a\u505a\u6cd5\uff0c\u6709\u4e9b\u4eba\u5219\u6301\u4fdd\u7559\u7684\u6001\u5ea6\u3002\u6765\u81ea\u53f2\u4e39\u4f5b\u5927\u5b66\u7684 John Ioannidis \u5173\u6ce8\u7814\u7a76\u7684\u53ef\u590d\u5236\u6027\uff0c\u4ed6\u6307\u51fa\u79d1\u7814\u754c\u8fd8\u6ca1\u6709\u5f00\u653e\u5230\u63a5\u53d7\u53d1\u8868\u8d1f\u9762\u7ed3\u679c\u8fd8\u6709\u590d\u5236\u7814\u7a76\u3002\u5b89\u8fdb\u7684\u505a\u6cd5\u662f\u5426\u80fd\u6210\u529f\u4eba\u6709\u5f85\u8003\u9a8c\u3002<\/p>\n<p>\u00a0<\/p>\n<p><strong>\u53c2\u8003\u8d44\u6599<\/strong><\/p>\n<p><a href=\"https:\/\/www.sciencemag.org\/news\/2016\/02\/if-you-fail-reproduce-another-scientist-s-results-journal-wants-know\" rel=\"nofollow\" style=\"font-size: 14px;\">If you fail to reproduce another scientist\u2019s results, this journal wants to know<\/a>\u00a0(accessed February 5)<\/p>\n<p><a href=\"https:\/\/www.nature.com\/news\/biotech-giant-publishes-failures-to-confirm-high-profile-science-1.19269#\/b1\" rel=\"nofollow\">Biotech giant publishes failures to confirm high-profile science<\/a>\u00a0(accessed February 5)<\/p>\n<p>\u00a0<\/p>\n<p style=\"text-align: center;\"><span style=\"color:#b22222;\">\u3010\u610f\u5f97\u8f91\u4e13\u5bb6\u89c6\u70b9\u6bcf\u5468\u7cbe\u9009\u4e00\u7bc7\u79d1\u7814\u53d1\u8868\u754c\u4eba\u58eb\u8be5\u5173\u6ce8\u7684\u65b0\u95fb\uff0c<\/span><a href=\"https:\/\/www.editage.cn\/insights\/user\/signup\" target=\"_blank\"><span style=\"color:#b22222;\">\u6b22\u8fce\u8bfb\u8005\u6ce8\u518c\u53d6\u5f97\u6700\u65b0\u6d88\u606f<\/span><\/a><span style=\"color:#b22222;\">\uff01\u3011<\/span><\/p>\n<p>\u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u603b\u90e8\u4f4d\u4e8e\u7f8e\u56fd\u52a0\u5dde\u7684\u8de8\u56fd\u751f\u7269\u5236\u836f\u516c\u53f8\u5b89\u8fdb\uff08Amgen\uff09\u5728 2 \u6708 4 \u65e5\u5ba3\u5e03\u5c06\u53d1\u8868 3 \u4e2a\u65e0\u6cd5\u786e\u8ba4\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u8fd9 [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":60567,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[597,591,55,696],"tags":[62,178,144],"new_categories":[],"new_tags":[],"series":[],"class_list":["post-39546","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-quan-qiu-qu-shi-198","category-fa-biao-pian-yi-140","category-hang-ye-xin-wen-31","category-fu-mian-jie-guo-235","tag-quan-qiu-qu-shi-198","tag-fa-biao-pian-yi-140","tag-fu-mian-jie-guo-235"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ 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